Identifying the subproteome of kinetically stable proteins via diagonal 2D SDS/PAGE

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Identifying the subproteome of kinetically stable proteins via diagonal 2D SDS/PAGE.

Most proteins are in equilibrium with partially and globally unfolded conformations. In contrast, kinetically stable proteins (KSPs) are trapped by an energy barrier in a specific state, unable to transiently sample other conformations. Among many potential roles, it appears that kinetic stability (KS) is a feature used by nature to allow proteins to maintain activity under harsh conditions and...

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15 صفحه اول

Stable Lattices and the Diagonal Group

Inspired by work of McMullen, we show that any orbit of the diagonal group in the space of lattices accumulates on the set of stable lattices. As consequences, we settle a conjecture of Ramharter concerning the asymptotic behavior of the Mordell constant, and reduce Minkowski’s conjecture on products of linear forms to a geometric question, yielding two new proofs of the conjecture in dimension...

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On Stable Lattices and the Diagonal Group

Inspired by work of McMullen, we show that any orbit of the diagonal group in the space of lattices accumulates on the set of stable lattices. As consequences, we settle a conjecture of Ramharter concerning the asymptotic behavior of the Mordell constant, and reduce Minkowski’s conjecture on products of linear forms to a geometric question, yielding two new proofs of the conjecture in dimension...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2007

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.0705417104